Sentence examples for binding to and modulating from inspiring English sources
Pro-apoptotic members of Bcl2 family of proteins like Bax and Bak are seen to promote Cytc release by binding to and modulating Vdac action [22].
It is also likely that anesthetics act by binding to and modulating K2P potassium channels.
Volatile general anesthetics are thought to act, at least in part, by binding to and modulating two pore domain potassium channels (K2P).
Members of the Cip/Kip family, p21Cip1 and p27Kip1, are implicated in the negative regulation of cell-cycle progression from the G1 to S phase by binding to and modulating CDK activity 8, 36– 36.
FusB-type proteins represent the predominant mechanism of resistance to fusidic acid in staphylococci and act by binding to and modulating the function of the drug target (elongation factor G [EF-G]).
Only in the last one and a half centuries, and mainly during the past few decades, have we begun to acquire the ability to create ourselves compounds with desired properties, such as binding to and modulating the activity (or expression) of specific proteins (1– 15).
One possibility is that the E3-defective Peli1 may exert an active role by binding to, and modulate the function of, other Peli family members.
Anti-cancer activity was later found to be due to the compounds binding to CRL4ACRBN and modulating the E3 ligase activity resulting in promoted degradative ubiquitination of several members of the Ikaros transcription factors family in a manner similar to auxin-mediated degradation of Aux/IAA, described above [ 186].
Abatacept is the first member of a new class of biologics which inhibit T-cell activation by binding to CD80/86 and modulating its interaction with CD28.
If TG2 inhibition acts independently of histone acetylation, how is TG2 then binding to chromatin and modulating transcription in the presence of mhtt?
In this study, we propose that via the same mechanism WWOX acts as an inhibitor of TGFβ signaling by binding to SMAD3 and modulating nuclear translocation of this transcription factor, thus reducing promoter occupation and transcriptional activation.
