XIAP prevents apoptosis by binding to and inhibiting caspases, and this inhibition can be relieved by IAP antagonists, such as Smac/DIABLO.
In addition to binding to and inhibiting Wnt signaling, SFRPs have been found to bind to Frizzleds directly, or in a complex with Wnts, thereby activating Wnt signaling.
Bevacizumab works by binding to and inhibiting the action of vascular endothelial growth factor (VEGF), which normally stimulates angiogenesis.
Cardiac glycosides are believed to increase the force of cardiac muscle contraction by binding to and inhibiting the action of a membrane enzyme that extrudes sodium ions from the cell interior.
The program's utility is demonstrated through analysis of a modularly assembled peptoid library that previously was screened for binding to and inhibiting a group I intron RNA from the fungal pathogen Candida albicans.
IAPs regulate apoptosis by binding to and inhibiting caspases [11].
Overexpressing Hmga2 induces pituitary tumours in mice by binding to and inhibiting retinoblastoma protein [42], a tumour suppressor.
Our ChIP analyses provide additional mechanistic evidence that CREB and E2F-1 negaffecty affect AP-2α transcription by binding to and inhibiting the activity of its promoter.
These overexpression experiments suggest that IGFBP-1a and -1b are inhibitory proteins and that they probably act by binding to and inhibiting IGF actions in vivo.
Thus, likely the benzothiazole linked to a triazine ring backbone may be the core structure for binding to and inhibiting ABCG2 function and stability.
These results suggest that IGFBP-2 is a conserved regulatory protein and it inhibits growth and development primarily by binding to and inhibiting IGF actions in vivo.
