Sentence examples for binding to and activation from inspiring English sources

Androgen exerts its biologic effects by binding to and activation of androgen receptor (AR) that trans-activates target genes through androgen responsive element (ARE) in the promoter of target genes [ 15].

The biologic functions of PTH are mediated by binding to and activation of G protein-coupled PTH receptor, which in turn activates the protein kinase A and protein kinase C signaling pathways [ 57].

Among all melanocortin receptors MC-1R has the highest affinity to α-MSH and it has therefore been suggested that many of the anti-inflammatory and immunomodulatory activities of α-MSH are mediated through binding to and activation of MC-1R [19], [19].

We therefore hypothesized that the activity of MMF on microglia may involve binding to, and activation of, this receptor.

Both analogs were potent inhibitors of binding to and activation of Notch1 by Notch ligands Dll1 and Dll4, but not by Jag1.

To this end, we have developed a new approach that now enables monitoring both binding to and activation of T cells by peptide MHC tetramers at the single-cell level.

AMOT may also directly activate Hippo pathway via physical binding to and subsequent activation of Lats1/2 kinase.

In addition, studies are required to gain further insights on how leptin mutations, not only this V145E mutation, but also other mutations identified in humans, affect the binding to and subsequent activation of leptin receptor.

However, in neuroblastoma cells, ERK activation involves retinoid binding to RAR and activation of PI3K independent of gene transcription [ 13].

Stable PGI2 analogues like iloprost and carbacyclin, also act as PPAR ligands, directly binding to and causing transcriptional activation of PPARα and PPARδ in vitro [4].

In MCF7 cells, STS transcription may be up-regulated by E2 via direct binding to ER and activation of estrogen response elements in the STS promoter regions.