Sentence examples for binding to an unknown from inspiring English sources
The selective localization in the prometaphase stage confirmed in four different cell lines strongly suggest the possibility of a functional binding to an unknown protein.
Similarly, targeting of CgB to granules depends both on its self-aggregation and binding to an unknown sorting receptor [19], which suggests that granins act as an assembly factor in the TGN that may recruit other proteins into the budding granule [16].
The inhibition of termination-reinitiation by the AON that targeted motif 1, in contrast, is highly consistent with its proposed role in binding to helix 26, although effects via RNA conformation or binding to an unknown molecule cannot be ruled out.
(A ) Epitope-tagged ISG15 3XFLAG-6His-ISG15 3XFLAG-6His-ISG15 3XFLAG-6His-ISG15 tarepresentedopeptide linkage.
It is also possible that system xc- inhibition by sorafenib is mediated by binding to an unknown or uncharacterized kinase, or a non-kinase target, neither of which would be resolved by a kinome-wide profiling experiment.
Binding to an unknown target can be influenced by cell absorption and transport, additional protein binding, secondary target interactions, drug metabolism, etc.
Fluoro-Jade Fluoro-Jade Bdye specificasly stanionicgenerating neurons by bindyeg to a currently unknown, mospecificallypoly-amine, bastainsbstance in the neuron.
Extracellular S100A4 targets tumour or endothelial cells by binding to an as yet unknown receptor and triggering a signal transduction cascade and/or perhaps by internalisation followed by interaction with the intracellular target proteins.
The investigators concluded that PGE2-G, likely through binding to an as yet unknown receptor, stimulates activation of PLCβ, leading to IP3 production, Ca2+ mobilization, PKC activation, and ultimately MAPK phosphorylation and activation.
Sanglifehrin A (SFA) is a novel immunophilin-binding immunosuppressive drug isolated from the actinomycetes strain Streptomyces A92-308110 exhighting high affinity binding to Cyclophilin A, but unknown mechanism of action [1] [4].
van Rossum et al. [47] observed S1P binding to a putative TRPC3-PLCγ1 intermolecular domain that also interacts with phosphatidylinositol phosphates; the functional relevance of this binding is unknown.
