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We find that entry of Tse6 into target cells requires its binding to an essential housekeeping protein, translation elongation factor Tu (EF-Tu).
Rather, BQ most probably inhibits the SH-dependent topo II by binding to an essential SH group.
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Feringa and colleagues substituted the azobenzene switch for a similar chemical grouping within several variants of an antibacterial molecule called a quinolone, which tackle some types of bacteria by binding to an enzyme essential for replicating DNA.
The HIV envelope protein (Env) is essential for binding to a human lymphocyte or T cell.
The compound attacks these and other gram-positive bacteria by binding to chemicals essential to forming cell walls, causing them to break down.
This prevents VKORC1 from binding to vitamin K, an essential step in blood clot formation.
Substrate binding to LAMP2A is an essential step for CMA, and cells use changes in LAMP2A levels to upregulate or downregulate CMA (Cuervo & Dice, 2000a, b; Massey et al, 2006a).
Our studies demonstrate that Brd4 binding to chromatin is essential for maintaining a properly organized chromatin conformation.
ATP binding to AAA1 is essential for the ring formation, consistent with previous studies14,15,19,46, while ATP binding to AAA2 is essential for the formation of hexameric rings.
The 1KT/AA mutant showed inhomogeneous and atypical oligomeric forms (Fig. 3a), consistent with the previous reports that nucleotide binding to AAA1 is essential for the assembly of ClpB14,15,19.
Therefore, binding to H3K27me3 is essential for LHP1 protein function.
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