Sentence examples for binding to adjacent sites from inspiring English sources

In the crystal lattice, two molecules form a tandem dimer upon binding to adjacent sites on DNA.

Overall, we observed that DNO supplementation improved BCO binding, consistent with a model in which efficient tag/anti-tag recognition is precluded by secondary structure in the BCO (Figure 4C), as well as with recent studies demonstrating oligonucleotide binding cooperativity between two oligonucleotides binding to adjacent sites on a single-stranded DNA [14].

Thus, these data indicate conservation of the overall regulatory regime of C/EBPα and PPARγ between mouse and human adipocytes, including their potential direct cooperativity through binding to adjacent sites.

Cumulatively, these results indicate that both PPARγ and C/EBPα are directly involved in the activation of the majority of adipocyte-specific genes and that they cooperate through binding to adjacent sites on DNA.

The reason for this discrepancy is that while NFAT can alone bind to and activate the CD40L promoter, binding to the IL2 promoter requires AP1 binding to adjacent sites.

Both cis-regulatory and trans-regulatory coding variation via MSR variants could affect the degree of pQ β-sheet interdigitation between the pQ tracts of TFs binding to adjacent sites in cis.

Furthermore, if TF binding to adjacent operator sites is cooperative, then response curve steepness would also be affected.

The Met4 and Met28 proteins contain bZIP domains, but they do not have any inherent sequence specificity either alone or in combination with each other; instead, they appear to require Cbf1 binding to an adjacent site to exhibit sequence-specific DNA-binding activity (Siggers et al. 2011).

5′-Inosinate binds to an adjacent site close to the binding site for glutamate.

Further kinetic studies revealed a mutual exclusivity of BQ covalent inactivation and competitive inhibitor binding to sites adjacent to Cys165, refuting the viability of the current strategy for developing more potent irreversible BoNT/A inhibitors.

We consider a simple theoretical model for two interacting transcription factor (TF) species, searching for and binding to two adjacent target sites hidden in the genomic background.