Sentence examples for binding to additional targets from inspiring English sources
NSC11668 and hitachimycin binding to additional targets may be primarily responsible for growth inhibition, such that spiroindolone-pocket binding, though legitimate, has little biological effect.
Therefore, a significant attrition rate in clinical trials in the last decades [2] was due to the unexpected binding of drug candidates to additional targets (off-targets [3] or anti-targets [4]) resulting in dubious pharmacological activities, side effects and sometimes adverse drug reactions [5].
Lack of intrinsic structures could render protein additional functions, including binding to different targets [ 4], transcriptional regulation, translational regulation, and cellular signal transduction regulation [ 5].
Furthermore, the sequence of the PCR products amplified using the PCR primers confirms that these primers are specifically binding to the target genes (Additional file 1).
Future research involving RNA binding proteins other than NOVA proteins is sure to capture additional target transcripts subject to dynamic gene regulation in neurons.
(XLSX 799 kb) Additional file 5: Confirmation of NEUROD2 binding to putative target genes identified by the ClosesetGene method.
Hence, there might exist a transcriptional regulatory loop whereby p63 in cooperation with additional TFs activates RFX5, which then in turn, modulates p63 binding to its target sites.
Promiscuous binding to several protease targets demonstrates the emerging importance of quantitative studies on binding specificity.
Resultant radioactive metabolites could also contribute to nonspecific binding or compete with the parental tracer for binding to the target.
Backes, S. et al. Tom70 enhances mitochondrial preprotein import efficiency by binding to internal targeting sequences.
