Sentence examples for binding to active targets from inspiring English sources

As the specific binding to active targets may have a profound impact on the overall pharmacological activity [32], the effects of a variety pattern of protein binding reflected in the uptake profiles by cell membrane on therapeutic efficacy of drugs could be adapted as a primary screening means.

PIAS3 acts by binding to active nuclear STAT3 (r18, event 57).

Combinations of kinase inhibitors, with each potentially binding to multiple targets, may be necessary to inhibit undesirable growth and proliferation signals active in neoplasms [35].

It seems to work by binding to multiple targets, she said, which may slow down the development of resistance.

This would also enable identification of fragments binding to the target protein outside the active site(s) which could be of potential interest for developing allosteric inhibitors.

Triclosan, unlike other biocides, at low concentrations has a single intracellular target by binding to the active site of the FabI.

For example, pan-assay interference compounds (PAINS) can show signs of activity in assays due to redox cycling, degradation, or other nonspecific processes that lead to a signal, even when not truly binding to a molecular target's active site (Baell and Walters 2014).

Promiscuous binding to several protease targets demonstrates the emerging importance of quantitative studies on binding specificity.

Energetics of cooperative ligand binding to the active sites of biosynthetic threonine deaminase from Escherichia coli.

Resultant radioactive metabolites could also contribute to nonspecific binding or compete with the parental tracer for binding to the target.

This mutation prevents GDC-0449 from binding to its target.