Sentence examples for binding to abundant from inspiring English sources

Fluorescent transferrin binding to abundant transferrin receptors on the plasma membrane can be seen in these pits but the uptake of transferrin is prevented.

The lower concentration of unchanged radioligand in plasma in baseline experiments may be ascribed to a depletion through binding to abundant TSPO receptors in peripheral organs that does not occur under TSPO blocking conditions.

Notably, our results show that AID binds structured RNAs in vitro (such as tRNAs), and preferentially targets tRNAs and other small RNA promoters for mutation in yeast, prompting the speculation that binding to abundant RNAs sequesters AID to subnuclear localities such as nucleolar areas, where small RNAs genes also localise during transcription.

Rapamycin (sirolimus) and its analogs, temsirolimus, everolimus, and deforolimus, inhibit the mTORC1 kinase by binding to an abundant intracellular protein, FKBP-12, forming a complex that inhibits the mTOR signaling.

This task is complicated by two factors: (i) the low association constants represent a challenge for the prediction methods; and (ii) the low-affinity binding to the abundant protein results in an easy replacement of the bound chemical by another, only slightly better ligand, with subsequent significant effects on the disposition of both compounds.

However, in order to be useful in vivo, probes must show selective high affinity binding to a sufficiently abundant binding site on amyloid plaques.

For the formulation of the QSAR models for large sets of diverse compounds eliciting the effects at the cell to organism levels, binding to the most abundant proteins must be analyzed and correlated with structures.

The physicochemical properties and biocompatibilities of HA-MRCAs were fully characterized, and their enhanced sensitivity with selective binding to the CD44-abundant cancer cells was comparatively investigated via MR imaging.

Non-specific binding of immunoglobulins to abundant plasma proteins may contribute to a background problem, limiting the availability of suitable highly specific antibodies ideally from different host animals to cancel out non-specific binding.

It is noteworthy that the results of staining with the TNF-binding antibody 2C8 differed from those obtained with mAb1 and mAb11 in the sense that 2C8 shows rather abundant binding to extracellular material adjacent to cells that are intracellularly stained with this antibody.

These findings are in line with a previously reported study by Khan and co-workers, where they have scrutinized the mechanism of ThT binding to the four most abundant serum albumin variants and found out that HSA has the highest affinity to ThT and that the intensity increased in a concentration dependent manner.