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PCR primers were tested In Silico using BLAT in UCSC to confirm their binding to a unique region of the genome and the absence of polymorphism.
Key features of this pathway, as identified in MRL/lpr mice, are (i) P140 binding to a unique receptor, the constitutively-expressed HSC70 chaperone protein; (ii) involvement of γδ T cells in a granzyme B- and caspase-dependent mechanism, leading directly or indirectly via cytotoxic effectors to apoptosis of distinct (activated) T and B lymphocytes/blasts.
Cooperative ATP binding to a unique pocket in the equatorial domains induces a downward rotation of the intermediate domains (Ranson et al., 2001; Ma et al., 2000).
The distinction of ofatumumab with regard to CDC induction was found to be linked to binding to a unique epitope on CD20 [ 35].
Moreover, it was shown that CREBH directly regulated human APOA5 gene expression by binding to a unique CREBHRE located in the proximal human APOA5 promoter region, using 5′-deletion and mutagenesis of human APOA5 promoter analysis and chromatin immunoprecipitation assay.
Although the inhibition constants mirror the KM values observed with quinone substrates, the observation that quinol binding is not competitive with either NADH or quinone substrates suggests that quinol inhibition results from binding to a unique site that affects both NADH-Q and transhydrogenase activities.
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Adenomatous polyps are thought to be precursors to CRC whereas hyperplastic polyps are not [31], [32], suggesting that the target peptide could be binding to a cell surface target unique to dysplastic and/or cancerous cells.
Printed books are of their time: testimony in ink, paper, typography, binding and design to a unique moment, delivering to our eyes and ears and hearts the voices from the past.
It mediates these functions via binding to its unique receptor c-Met, a receptor tyrosine kinase.
In both structures, the substrate H2O/OH− molecule exhibits binding to the unique Fe site of the C-cluster.
CDP acts as a transcriptional repressor by binding to unique nucleotide sequence elements and is also involved in the regulation of gene transcription through nuclear matrix attachment (22).
More suggestions(18)
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binding to a potential
binding to a specialized
binding to a regulatory
binding to a putative
binding to a Rho-type
binding to a small
binding to a light-reactive
binding to a hydrophobic
binding to a human
binding to a nearby
binding to a representative
binding to a magnetic
binding to a novel
binding to a palindromic
binding to a negative
binding to a broad
binds to a unique
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