Sentence examples for binding to a target from inspiring English sources

CETSA therefore provides a feasable alternative to measure binding to a target where traditional biophysical methods are not possible, for example when recombinant protein cannot be produced.

DARPins are a novel class of proteins selected for specific, high-affinity binding to a target protein.

This protein could be subjected to binding analyses using D-CaM, a dansylated derivate that reports conformational changes of CaM as an increase in fluorescence emission upon binding to a target protein38,39,40.

miRNAs work as post-transcriptional regulators by binding to a target sequence located within the 3′ UTR of the mRNA, promoting degradation of the mRNA or inhibiting translation of the mRNA.

We present structural and dynamical evidence for allosteric effects in a PDZ domain, PDZ2 from the tyrosine phosphatase PTP-BL, upon binding to a target peptide.

STD-NMR is a promising tool for rapid screening of a large library of compounds to identify bioactive ligands binding to a target protein.

These include "Off-target" adverse effects caused by a drug binding to an unexpected target and "On-target" adverse effects as a result of a drug binding to its intended target that is not only present in tumor cells, but also found in normal tissue [ 26].

With the advancement in information technology, the dynamic understanding of drug binding to a specific target protein can be achieved using molecular dynamics simulation (MD) approach.

At the heart of the screening for fragments binding to a specific target, crystallography delivers structural information essential for subsequent drug design.

Again this is highly relevant for screening where the biological end point is based on phenotypic changes rather than on binding to a specific target.

These protein fragments are considered antibody-mimetic because, like antibodies, each protein fragment is composed of a constant region, which stabilizes the overall protein folding, and multiple variable regions that mediate its binding to a specific target.