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The Freundlich equation is the empirical relationship whereby it is assumed that the adsorption energy of binding to a site on an adsorbent depends on whether or not the adjacent sites are already occupied.
Eighteen novel neamine nucleoside conjugates with ethylenediamine lysine or ethylenediamine arginine as the linker were synthesized and their potential binding to A site of 16S RNA and TAR RNA was evaluated using SPR (surface plasmon resonance).
According to the data of SPR, it indicates that amino acid residue and nucleobase moieties of the designed neamine nucleosides conjugates exhibit the important contributions for the binding to A site of 16S RNA and TAR RNA.
The MADF domain directs sequence specific DNA binding to a site consisting of multiple trinucleotide repeats, while the BESS domain directs a variety of protein protein interactions, including interactions with itself, with Dorsal, and with a TBP-associated factor.
Compared with neamine, compounds 10i and 10q show 6.3 and 4.8 times potential in binding to A site of 16S RNA and eight and six times potential in binding to TAR RNA, respectively.
It's binding to a site extraneous to the P-loop explains CTP's incapacity to donate a phosphoryl group despite its strong binding to the enzyme.
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The analysis revealed that in the case of three isoforms (smTM, TM1b9a and TM5a) the affinity to an isolated binding site (Ko) was reduced and binding to a contiguous site was increased by modification of the actin C-terminus.
The protein, Runx-1, controls the activity of various genes by binding to a nearby site on the DNA of the chromosomes.
We then asked whether 17B1.3 prevents signaling by binding to a putative site for B7-H6 dimerization.
In order to determine whether P5 was binding to a specific site in LNCaP cells, receptor binding studies were performed.
In vivo assessment of tracer binding to a receptor site is based on the principles of receptor pharmacology [5].
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