Sentence examples for binding to a second from inspiring English sources
Interaction of IgE with the α-subunit of one FcεRI prohibits concomitant binding to a second FcεRI α-subunit [ 16].
Subsequent binding to a second identical receptor molecule via binding site 2 results in the active 1 2 ligand receptor complex.
Our results provide no indication that pEndos inhibits PP2A-B55 bindinging to a second, allosteric site separate from the active site at which it is dephosphorylated.
Chicken ovalbumin upstream promoter-transcription factor II modulates gene expression by either activation or repression through direct binding to response elements in DNA or by binding to a second transcription factor in tissue-specific and gene-specific manners (Litchfield and Klinge, 2012).
The protein trans-actives transcription from the native Hor2 promoter through binding to a third motif (5'-AACA/TA-3') that is present in endosperm-specific genes.
More specifically, it has been proposed that Dpl competes for a putative PrPC ligand that is necessary to transduce a cell survival signal [ 15– 17] or that PrPC could block a neurotoxic signal induced by Dpl by competing for its binding to a third molecule, α-2-macroglobulin [ 8, 18].
Both Geldanamycin (GA), which binds to the N-terminal ATP-binding site of the protein [ 22], and Novobiocin (NB), which binds to a second ATP-binding site on the C-terminal domain [ 23] are global Hsp90 inhibitors: that is, they are known to block both Hsp90 isoforms (α and β), which share about 80% homology, and maybe other factors.
Thereafter another part of the ET-1 molecule binds to a second distinct binding-site on the receptor (site L).
Likewise, the endocytic clearance of MMP-13 by LRP-1 requires a two-step process, involving a first binding to a 170 kDa co-receptor [ 51].
IgG binding to a peptide analogue of the second extracellular β1AR loop (Pep 2) was quantified by ELISA following published procedures.
However, if the second ligand binds to a separate second binding site, a resulting conformational change could lead to cooperative (allosteric) effects and thus affect the dissociation rate of the first ligand (23, 28– 30).
