Sentence examples for binding to a region from inspiring English sources
Although both macrolides and ketolides bind strongly to a region of domain V in the 23S rRNA of the ribosome, telithromycin has additional strong binding to a region in domain II to which the macrolides bind weakly [ 20].
Probes showing strong secondary structures or binding to a region of the target with such a strong secondary structure were not used.
It should be noted that SU5402 blocks FgfR1 activity by binding to a region well conserved in all four FgfRs, and so it might act on several of these receptors [32].
In recent study, Witcher and Emerson identified CTCF binding to a region (∼1.8 kb) upstream of the RASSF1A promoter [33], which was further refined to exon 7, intron 8, and intron 11 of BLU gene by our study.
It does so by binding to a region within the genes called the promoter.
The repression of Psl production occurs at the transcriptional level, by binding to a region overlapping the pslA promoter [ 7].
We further elucidated the relationship of these factors: the 3p strand of miR-34a directly targeted OCT4 by binding to the 3′ untranslated region (3′-UTR) of OCT4 and, OCT4, in turn, stimulated p63 but inhibited p53 expression by binding to a specific region of the p63 or p53 promoter.
During early-phase drug development, typically, such in vitro studies are conducted under closed-system conditions as saturation and competition experiments, which provide quantitative parameters for the extent of compound binding to a target region (e.g. receptor) according to the law of mass action [1].
These data together suggest that ultra-low-dose NLX prevents analgesic tolerance in response to chronic morphine by binding to a specific region of FLNA.
More recently, a 3D mapping study has located the IpTxA binding to a RyR region between the clamp domain and the central handle domain [55].
PCR primers were tested In Silico using BLAT in UCSC to confirm their binding to a unique region of the genome and the absence of polymorphism.
