Sentence examples for binding to a novel from inspiring English sources

Weitz-Schmidt, G. et al. Statins selectively inhibit leukocyte function antigen 1 by binding to a novel regulatory integrin site.

In addition to their activation via binding to cyclins, cyclin-dependent kinases (CDKs) can be activated via binding to a novel cell cycle regulator termed Speedy/Ringo, which shows no apparent similarity to cyclins.

Elecrophoretic mobility-shift and chromatin immunoprecipitation assays indicated that FXR induced TM expression by binding to a novel FXR-responsive element (FXRE), an inverted repeat DNA motif, IR8 (-503 AGGTCCtcccaaagTGCCCT-484) in the promoter region of TM gene.

One such antibody, MAb 9F4 was shown to provide heterologous protection against multiple H5N1 clade viruses, including one of the recently designated subclades, namely 2.3.4, through binding to a novel epitope, warranting its further development and characterization as a therapeutic candidate.

Notably, we observed repressed NFAT binding to a novel DNA binding site in the P2 promoter of HNF4alpha.

Second, the biofragment library is screened (fragment-based screening cascade) for binding to a novel putative ligand-binding protein from that class.

The inhibitors bind to a novel binding site, completely conserved between rat and human, at the interface between the ion channel and linkers connecting it to the ligand-binding domains.

We now report that p53 protein is transcriptionally activated in NGF-mediated neuronal differentiation and describe its binding to a number of novel and previously unreported genomic regions as well as the transcriptional outcome of this binding.

Here, we report on an innovative artificial protein, named CJ7, that consists of Jazz DNA binding domain fused to a novel activation domain derived from the regulatory multivalent adaptor protein Che-1/AATF.

Competitive displacement assays with an endogenous ligand may fail to detect the binding of a noncompetitive ligand to a novel binding site.

We found that C/EBPβ, but not HIF1α, regulates Vegf gene expression by binding to the novel binding site in the rat Vegf promoter region.