Sentence examples for binding to a low from inspiring English sources

Cyclic AMP production is reduced during agonist binding to a low affinity state.

Ivermectin is thought to have an allosteric mode of action by increasing maximum current when binding to a high affinity site on the receptor to stabilise the open state, whereas binding to a low affinity site is proposed to slow the rate of deactivation [ 44].

This could indicate that the kinase is activated by calcium binding to a low-affinity calcium-binding site within the protein itself or as part of a kinase-activating step.

These results are reminiscent of the effects of Mg2+ ions at a similar concentration on L-type channelsnels, which occurs by their binding to a low-affinity site at the pore of the α 1 subunit [ 37].

Hence, we speculate that the hydrophobic tail (Trp Val) of ChM-I may assist with its signaling by facilitating the presentation of its disulfide-bridged core structure (Cys Cys) to the putative ChM-I receptor through the binding to a low-affinity site or co-receptor.

In the presence of Wnt ligand binding to a FZD receptor and a low density receptor (LRP) coreceptor leads to the phosphorylation of disheveled protein in the cytoplasm (DVL).

The mutant protein failed to bind to collagens types I and II in an established solid-phase binding assay, displaying similar low-level binding to a DDR2 variant harboring the p.W52A mutation (Fig.  7B and C).

This low efficiency has been attributed to rapid saturation of easily accessible binding sites on the membrane as well as inefficient use of less accessible binding sites due to a low convective driving force.

However, the low binding score points to a low affinity for this molecule (Supplementary Table S3).

Such a high energy barrier is consistent with the rigid structure of the retinal binding site, leading to a low noise that is a prerequisite for highly sensitive dim light vision (see section 4).

Because linagliptin is predominantly eliminated without involvement of hepatic metabolizing function, high enzyme binding, in addition to a low rate of hepatic metabolism, results in hepato-biliary excretion of predominantly unchanged linagliptin.