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After binding to a ligand, CRP binds to Fc γ receptors on phagocytic cells and thus mediates ligand elimination from the body.
From our experiments, we observed that TLR9 predominantly forms dimers prior to binding to a ligand.
Systematic Evolution of Ligands by EXponential enrichment (SELEX) is an in vitro strategy to analyze RNA sequences that perform an activity of interest, most commonly high affinity binding to a ligand [1].
The concept makes use of the conformational change of a sensory protein when binding to a ligand.
ERaD5, a constitutive mutant variant, is characterized by the capability to activate transcription of ER-dependent genes without binding to a ligand [ 8, 9].
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The ligand binding assay was a variant of the ELISA in which dilutions of ligand (rhFGF-2) were allowed to bind to a ligand binding protein such as rhPln.D1 that had been coated onto the wells in PBS-N3.
These membrane receptors can induce autophagy upon binding to a cognate ligand [ 144].
Our data model makes it possible to describe Minimal Aptamers, which are sub-sequences or variants of larger sequences that exhibit binding to a target ligand.
After binding to an activating ligand, such as corticosteroid, the glucocorticoid receptor (GR) performs an impressive array of functions ranging from nuclear translocation, oligomerization, cofactor⧸kinase⧸transcription factor association, and DNA binding.
Lectin binding to a single saccharide ligand is typically a low-affinity interaction.
Second, the biofragment library is screened (fragment-based screening cascade) for binding to a novel putative ligand-binding protein from that class.
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