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Many of the nearly 200 established mammalian PIPs are predicted to be intrinsically disordered, a property that facilitates their binding to a large surface area of PP1 via multiple docking motifs.
In utilizing binding to a large receptor molecule, it may be important that the spike S1 domain also acts as a "spacer arm" holding the receptor far enough away from the three-fold axis of symmetry of the spike S2 domain to permit fusion core re-arrangement and subsequent membrane fusion.
The 14-3-3epsilon 14-3-3epsilon 14-3-3epsilonbinding to a large number of other proteins is alsoosphorylation-dependent manner.
The modular Ig-like domain repeats allow binding to a large number of host proteins since each Ig-like domain may exhibit different specificities.
The widespread functions regulated by Hsf1 explain its binding to a large number of promoters (about 3%% of the genes in the yeast genome).
Each PRR comprises two putative overlapping Src homology 3 (SH3) binding domains with the consensus PxxP motif that is reported to mediate the binding to a large number of eukaryotic signaling proteins containing the well-characterized SH3 domain [ 109].
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Odorants activating a smaller subset of an OR population may also be binding to a larger subset of ORs, resulting in mixture inhibition.
Moreover, the CTCF-binding peak is offset from the center of the M1 motif, consistent with CTCF binding to a larger, directional 33/34 bp motif.
This work provides a more general view of Ca2+-binding to a large group of proteins, i.e., Big domains.
These proteins differ from classical C-type lectins in that they lack the calcium and sugar-binding loop and instead bind to a large variety of proteins and receptors involved in hemostasis, including coagulation factors IX and X and various blood platelet receptors [ 72].
Previous work identified proteins regulated by hfq using purification of the RNA-protein complex with direct sequencing of the bound RNAs and found binding to a surprisingly large number of transcripts.
More suggestions(16)
impediments to a large
consolidating to a large
binding to a specific
binding to a single
binding to a putative
binding to a light-reactive
binding to a nucleosome
binding to a particular
binding to a human
binding to a nearby
binding to a same
binding to a key
binding to a one-dimensional
binding to a specialized
binding to a complementary
binding to a small
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