In summary, rather that representing the classical view of one antibody binding to a protein like a key fits a lock, these, and many other examples we have not cited, lead us to the conclusion that the 'key' may fit many types of 'locks' and the lock can fit an array of different keys.
Cellular and viral forms of FLIP can also attenuate autophagy through inhibitory binding to Atg3, a key component of the LC3 conjugation system.
Typing "WIKIHOW", for example, binding it to a key, and using it will write the word WIKIHOW.
Importantly, RAC1, CDC42, RHOG, and RHOA preparations bound similar amounts of GTP, indicating proper folding and functionality, and a RAC1-I33D mutant showed reduced binding to p110β, confirming a key role of this residue in GTPase binding to p110β.
These results suggest that IRAK-M induced by HA2700 binding to CD44 has a key role in downregulation of the IL1α-stimulated signalling pathway, and MEK is involved in the ERK1/2 phosphorylation.
Silver has been proposed to act by binding to key functional groups of enzymes.
Cpn can downregulate HH signaling pathway activity by binding directly to SMO, a key component of the HH signaling pathway [ 27, 28].
SINCE the discovery of sequence-specific binding of the λ-phage repressor to operator sites (Gilbert and Müller-Hill Müller-Hillne 1967), the Ptashnele of sequence-specific binding has been a key to understanding gene regulation, DNA replication, genome defense, and other basic genetic processes.
2. Bermudez M, et al. Structural characteristics of the allosteric binding site represent a key to subtype selective modulators of muscarinic acetylcholine receptors.
This may be useful when the property of interest is related to a biochemical process in which binding plays a key rôle.
