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We note here that infection by an exogenous retrovirus involves binding to a host cell receptor.
CCR5 antagonists inhibit virus entry by binding to a host cell protein, the CCR5 receptor, and inducing an allosteric change which renders the molecule unrecognizable to wild type R5 HIV.
PfRom1 was shown to be able to cleave AMA1 [ 88]; (2) the erythrocyte binding-like (EBL) family is involved in binding to a host chemokine receptor, the Duffy antigen [ 98].
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A cryptophane-radon association constant was determined, KA=(49,000±12,000) L mol−1 at 293 K, which was the first measurement of radon binding to a molecular host.
However, the molecular mechanisms of targeting and covalent binding to a relevant host receptor have yet to be discovered.
P. falciparum expresses PfEMP-1 cytoadherence proteins and concentrates them in knob-like protrusions on the RBC surface, where they mediate binding to a variety of host cells.
These proteins contribute to pathogenicity by binding to a range of host factors mediating adhesion, invasion and resistance to the complement response.
PfEMP1 is a major adhesin that mediates binding to a variety of host-receptors causing sequestration of IEs in the microvasculature of various organs and severe disease in children and pregnant women.
The modular Ig-like domain repeats allow binding to a large number of host proteins since each Ig-like domain may exhibit different specificities.
Moreover, this reduction in HIV-1 infectivity was also size dependent, as only silver-containing nanoparticles ranging from 1 to 10 nm in diameter established a strong enough physical interaction with the gp120 glycoprotein of HIV-1 virions to inhibit viral binding to a host cell [6].
Passenger domains consist of a secretion sequence, a head region that facilitates binding to the host cell surface, and a stalk region.
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