Sentence examples for binding to a diverse from inspiring English sources

The understanding of how small molecules can modulate the function of this important class of receptors by binding to a diverse range of pockets on and inside the proteins has had a profound impact on the structure-based drug design (SBDD) of new classes of therapeutic agents.

Although the functional significance of most of these sites remains to be assessed, regulation by E2F upon binding to a diverse group of sequences, such as 5'-GGGCGGGC-3' and 5'-GCTCCAAA-3', has been demonstrated for the ASK-1, and the carboxylesterase gene promoters, respectively [8], [9], [10].

P. falciparum IEs have been shown to have the potential for binding to a diverse array of endothelial receptors (Table 1).

In addition to its lymphangiogenic role, COX-2-upregulated VEGF-C directly promoted breast cancer cell motility, a phenotype for metastasis, by binding to a diverse group of VEGF-C receptors.

We were unable to identify a group of food-allergic people with markedly different outcomes, however previous work has identified that those with asthma, previous severe reaction, IgE binding to a diverse range of epitopes, deficient platelet-activating factor acetyl-hydrolase or serum angiotensin-converting enzyme may have more severe food-allergic reactions [ 28– 30].

In the S. aureus multidrug binding repressor protein QacR, which binds to a diverse yet precise array of cationic compounds, it was predicted that glutamate residues lining the multidrug binding pocket would play a key role in drug binding affinity.

Consistent with this, Plin2 is known to support binding to an array of lipids with diverse structures such as phospholipids, sphingomyelin, cholesterol, and fatty acids.

The structural subunit is able to support binding to such diverse B-subunits because each family interacts with a unique, but overlapping face of the structural subunit.

Studies have indicated that AHR is a promiscuous receptor that is capable in binding to diverse chemicals, leading to their activations [ 1].

With the use of phage-display library, the series of peptides binding to diverse VCAM-1 epitopes was identified, some of which have shown enhanced uptake.

This recognition is achieved by the binding of spliceosomal components (trans-factors) to a diverse array of intronic and exonic splicing sequence elements (cis-elements).