Sentence examples for binding to a distinct from inspiring English sources

The VAR2CSA mediated binding to a distinct chondroitin sulphate A (CSA) is a crucial step in the pathophysiology of placental malaria and the CSA binding region of VAR2CSA has been identified as a promising vaccine target against placental malaria.

A parameter called a 'prior' assigns an a priori probability of TFs binding to a distinct sequence.

The antagonist/agonist activity of some antiandrogens is thought to be due to different actions on the AR receptor whereby the AR is simultaneously stimulated by binding to a distinct domain of the receptor (Tamura et al. 2006).

Finally, increased intracellular levels of aminoacids, particularly arginine and leucine, promote mTORC1 activation, by inducing its binding to a distinct family of GTPases, the Rag GTPases, together with its translocation to the lysosomal surface [ 19, 20].

If K+ and Mg2+ act by binding to a distinct binding site at the surface or in a more buried location, this site would be additional to that which binds Na+ selectively.

For off-targets from the NKX2-5WT Y191C comparison, NKX2-5 WT modulated the expression of 6/22 C-set genes tested by > 1.5-fold, although the effect on 2 of these (Dock4 and Sparc) could be accounted for by NKX2-5 WT binding to a distinct DamID peak, and consistently, NKX2-5 WT and Y191C had opposite effects on these two genes.

Rather than acting directly by blocking the glutamate orthosteric binding site, ADX10059 modulates the activity of the mGluR5 receptor by binding to a site distinct from the glutamate binding site (ie, an allosteric site), and diminishes the intra-cellular signal created when glutamate binds to the receptor.

Therefore, any changes of the dissociation rate of 3 nM BODIPY-TMR-CGP from the high-affinity β1-adrenoceptor conformation would be caused by the unlabeled β-adrenoceptor ligands CGP 12177 and propranolol binding to a topographically distinct (allosteric) binding conformation that exerts a cooperative effect on the high-affinity (orthosteric) conformation.

Of particular importance is whether switch loop closure is triggered by ATP binding (as in the gamma phosphate sensor scheme) or by some other event, which would allow ATP binding to have a distinct function.

Here, all antibodies except PaD213-A5 showed no predominant binding to any distinct form.

Allosteric modulators have been considered so far as molecules binding to an allosteric site, distinct from that of the reference ligand (orthosteric site), and able to modulate the binding affinity at the orthosteric site and/or the signaling properties resulting from orthosteric site occupancy.