Sentence examples for binding to a conserved from inspiring English sources

As part of the ubiquitination and downregulation process, c-Cbl recognizes targets, such as tyrosine kinases and the Sprouty proteins, by binding to a conserved (NX/R pY(S/T XXP motif via its uniquely embedded SH2 domain (TKB domain).

Here we provide evidence that p63, specifically the ΔN isoform also regulates the expression of the K5 gene by binding to a conserved enhancer within the 5' upstream region.

In E. coli, CheR methylation activity is strongly enhanced upon binding to a conserved pentapeptide sequence (NWETF) at the C-terminus of highly abundant MCPs [38], [39].

This protein has been shown to induce stability by binding to a conserved sequence in the 3'- untranslated region (UTR) of insulin mRNA [6].

Restriction to variable heavy chain gene IGHV1-69 in the high affinity mAb panel was associated with binding to a conserved hydrophobic pocket in the stem domain of HA.

Wnts mediate these effects by binding to a conserved coreceptor complex and activating one of several downstream signaling cascades.

In one of the recent publications, HoxC4 was implemented into the AID promoter regulation via binding to a highly conserved HoxC4-Oct site; this site functions in synergy with a conserved binding site for the transcription factors Sp1, Sp3, and NF-κB [ 16].

The function(s) of p120 protein family members are targeted to membrane junctional regions where cell-cell interactions occur and include stabilization of cadherins by binding to a highly conserved sequence in the juxtamembrane region [26] [28].

It should be noted that SU5402 blocks FgfR1 activity by binding to a region well conserved in all four FgfRs, and so it might act on several of these receptors [32].

7– 9 Recently, miR-181 has been identified as a positive regulator of immune response, and miR-181 mimics have been shown to strongly hinder porcine reproductive and respiratory syndrome virus replication in vitro by specifically binding to a highly (over 96%) conserved region in the downstream of open reading frame (ORF) 4 of the viral genomic RNA.

Rapamycin binds to a highly conserved cytoplasmic receptor FK506-binding protein-12 (FKBP12).