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As peptides containing sulfo-tyrosines are difficult to synthesize and handle due to limited stability of the sulfo-ester moiety, we have now incorporated TYS isosteres into CCR5 Nt analogs and assessed their binding to a complex of gp120 CD4 using saturation transfer difference (STD) NMR and surface plasmon resonance (SPR).
In eukaryotes this structure involves DNA binding to a complex of small basic proteins called histones, while in prokaryotes multiple types of proteins are involved.
RA, a physiologically active form of vitamin A, regulates gene expression by binding to a complex of retinoic acid receptors (RARs) and retinoid X receptors (RXRs).
Since it has been postulated that AECA reactivity may be due in part to the binding to a complex of β2-GPI with phospholipids on endothelial cells [ 32, 33], we evaluated anti-β2-GPI and anti-CL antibodies by means of ELISA.
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Solutes are extracted by binding to a complexing agent present in the contacting phase and released to a receiving phase by converting the complexing agent electrochemically to a form with low affinity.
In the case of NDUFAF1, a chaperone not found associated with mature complex I, PGZ induced its binding to a new complex of 600 kDa, likely the subcomplex B formed after fragmentation of complex I.
This method gives information on the amount of ligand binding to a specific complex with a thermodynamic constant, Ktherm, that differs from Kcond ML.
Ciliary neurotrophic factor (CNTF) induces neuronal differentiation and promotes the survival of various neuronal cell types by binding to a receptor complex formed by CNTF receptor α (CNTFRα), gp130, and the leukemia inhibitory factor (LIF) receptor (LIFR).
IL-17A mediates its biological effects through binding to a receptor complex consisting of IL-17RA and IL-17RC subunits which are expressed in RA FLS [10].
With the C-terminal laminin G domain motoneuron-derived agrin affects NMJ formation and maintenance by binding to a receptor complex in the muscle membrane consisting of MuSK (muscle-specific kinase) and LRP4 (low-density lipoprotein receptor-related protein 4 [11], [12].
All human TGFβ isoforms (TGFβ1-3) signal by binding to a heterotetrameric complex of transmembrane serine/threonine kinase receptors [ 21].
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