Sentence examples for binding to a complementary from inspiring English sources

It ends up binding to a complementary messenger RNA sequence, and what we want to do is have this marker that can then pull down microRNA 375, which will also bring down anything that is bound to it," says Villanueva.

Antisense oligonucleotides act as exogenous inhibitors of gene expression by binding to a complementary sequence on the target mRNA, preventing translation into protein.

An antisense drug, designed to look like the original DNA, could interrupt that process by binding to a complementary stretch of RNA and destroying it.

The best studied non-coding RNAs are microRNAs (miRNAs), 18 25 nt-long small RNA that epigenetically regulate translation by binding to a complementary "seed" sequence common to their "target" mRNA [2].

The positively charged D-domain is essential for MEK binding to a complementary acidic common docking domain in the carboxy-termini of ERK1 and ERK2 [ 20, 21].

MicroRNAs (miRNAs), short non-coding RNAs, are endogenously expressed and directly inhibit protein translation by binding to a complementary target mRNA.

The use of antibodies conjugated to an oligonucleotide binding to a radiolabelled complementary oligonucleotide was also proposed a few years later (Bos et al. 1994; Liu et al. 2002).

In 7 out of 34 patients with PR3-ANCA-associated vasculitis, Pendergraft et al. found antibodies binding to a protein complementary to the middle part of PR3, and therefore named cPR3m [12].

Among the elements used in this study to reduce AUG codon accessibility were LNA oligonucleotides, which contain modified ribose sugars in which the 2'-O and 4'-C atoms are linked via a methylene group that locks the ribose conformation and confers high binding affinity to a complementary sequence [16] as well as high nuclease-resistance [20].

miRNAs exert their effects by complementary base-pair binding to a short 7 8 nucleotide seed region typically located on the 3′ untranslated region of the messenger RNA which they inhibit6,9.

However, miRNAs can also function to positively regulate gene expression by binding to complementary or partial complementary sequences in the promoter regions of genes (Place et al, 2008).