Sentence examples for binding to a common from inspiring English sources

Taking into account the similitude of BCLXL α9 with BAX α9 it has been proposed that BCLXL α9 plays a role in BAX retrotranslocation by competing with BAX α9 for binding to a common mitochondrial receptor or by directly extracting BAX away from the membrane [26, 38,39,40].

Despite the lack of sequence similarity to each other or to microcin J25, a prototypical lasso peptide and transcription inhibitor from Escherichia coli, acinetodin and klebsidin also inhibit transcript elongation by the E. coli RNA polymerase by binding to a common site.

While the nonbenzodiazepines are by definition structurally unrelated to the benzodiazepines, both classes of drugs possess a common pharmacophore (see figure to the lower-right), which explains their binding to a common receptor site.

To immunostain Germinal Centers (GC), the sections were incubated with biotinylated peanut agglutinin lectin (PNA), whose binding to a common carbohydrate sequence distinguishes monocytes, macrophages and particularly centroblasts (Vector Laboratories, Burlingame, CA, USA).

This would resemble the differential sensitivity of mammalian and avian TRPV1 channels to both exogenous and endogenous ligands (capsaicin and anandamide, respectively) that likely activate the channel by binding to a common site [21].

They can form separate heterodimers by binding to a common 30-kDa small regulatory subunit CAPNS1.

Also, the flexibility of intrinsic disorder helps different disordered regions to bind to a common binding site on a common partner.

We previously suggested that disordered segments with different sequences could use their flexibility to bind to a common binding site, thereby facilitating many-to-one signaling [ 35].

It is therefore very likely that OT binds to a common binding site that is located in between those four residues (Arg, Phe, Tyr and Phe) as proposed in the OTR model.

As different from ours, phenytoin inhibited Na+ channels in N4TG1 mouse neuroblastoma cells with an IC50 value comparable to that of lamotrigine [ 21], and phenytoin, lamotrigine, and carbamazepine were suggested to bind to a common binding site of Na+ channels in rat hippocampal CA1 neurons [ 22].

The positively charged D-domain is essential for MEK binding to a complementary acidic common docking domain in the carboxy-termini of ERK1 and ERK2 [ 20, 21].