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Because the preS domain acts in binding to a cellular receptor of hepatocytes, our findings implicate the exclusion of SVPs as competitors for the receptor binding and entry of virions.
Stx1 and Stx2 each comprise an A subunit monomer, which plays a role in toxicity, and a pentamer of B subunits, which are involved in binding to a cellular receptor, globotriaosylceramide (Gb3) (Lingwood et al. 1987; Stein et al. 1992; Fraser et al. 1994).
The fiber knob domain mediates the initial virus-cell interaction by binding to a cellular receptor.
Although both soluble and membrane bound CD14 are involved in inflammatory signalling pathways, CD14 is only part of a receptor complex and soluble CD14 needs binding to a cellular signal-transducing receptor in order for cell activation to occur [ 46].
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The biological activities of IL-2 are mediated through its binding to a multisubunit cellular receptor.
34 Non-synonymous Single Nucleotide Polymorphisms (nsSNPs) result in amino acid substitutions and may alter the number of cysteine residues available to arsenic for binding to a protein cellular target.
In contrast, wild-type p53 might accumulate in some tumors as a result of a response to DNA damage or by binding to other cellular proteins, giving a positive IHC result.
Most neurotransmitters are polar organic compounds that exert their signaling effect by binding to cellular receptors located at the cellular membrane.
The 14-α-lipoyl andrographolide (AL-1) could directly interfere with an influenza hemagglutinin to block binding to cellular receptors in a potentially new and potent mechanism of action [ 14].
The cellular tropism of Ad serotype 5 (Ad5)–based vectors is regulated by the Ad attachment protein binding to its primary cellular receptor, the coxsackie and adenovirus receptor (CAR).
Additional design requirements included association of Ad virions and targeting ligand without self-aggregation of the system components or binding to natural cellular proteins.
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