Sentence examples for binding to a Rho-type from inspiring English sources

So far, binding to a Rho-type GTPase like Rac has not been reported for Als2cL.

5 The DRF contain an N-terminal Rho GTPase binding domain (GBD) which, upon binding to a Rho family GTPase, alleviates autoinhibition of inactive DRF.

The activation of the first kinase, MAPKKK, is initiated by it binding to an activated Ras or Rho family protein.

ROK-α is a direct effector of the Rho GTPase, which is activated by binding to active Rho [ 63].

However, neither direct binding to the Rho GTPases nor GEF activity was detected in this study.

In order to further determine whether C1 specifically detected Rho proteins in their GTP-bound conformation, we next assayed C1 binding to Rho protein preloaded with GTP.

Once activated, Rho GTPases bind to a variety of effectors, including protein kinases and some actin-binding proteins.

Equilibrium binding analyses revealed affinity constants (KD) of 170 ± 30 nM and 1.9 ± 0.2 μM for EhPAK4 and EhPAK5 PBDs, respectively, as well as a high degree of nucleotide state selective binding to EhRacC, typical of Rho GTPase/effector interactions.

The Rho-type GTPase Rac1 also appears to be associated with TLR2-mediated signaling.

RAC/ROPs are RHO-type GTPases and are known to play diverse signalling roles in plants.

Balancing these promigratory functions, tetraspanin association may also allow the laminin-binding integrins either to generate a Rho-suppressive signal or to avoid activating Rho to the same extent as other integrins, resulting in a low basal level of Rho activity compatible with stable adherens junctions.