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Despite this enrichment, some crosslinks do not correspond to canonical sites to the relevant miRNAs, raising the prospect that these results might reveal novel types of non-canonical binding that could mediate repression.
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Since the underlying cause of this induction is proposed to be linked to a transcriptional mechanism [13] [17], we cloned a proximal sequence of the PGC-1α promoter and analyzed this fragment with stringent computer-assisted analyses to identify candidate transcription factor binding sites that could mediate the AICAR effect.
Therefore, we analysed the 2 kb upstream promoter fragment to identify candidate transcription factor-binding sites that could mediate gene activation during differentiation.
We used yeast 2 hybrid screens to identify novel binding partners of R-Ras that could mediate its effects on integrin function.
In support of this idea, in silico analysis of the Tagln promoter sequences present in TetOn(Tagln-Hoxc11) revealed the presence of 13 bona fide AbdB-type HOX binding sequences (Benson et al., 1995) that could mediate this selective transgene repression.
Since ETS factors can act as transcriptional activators or repressors depending on the promoter context [10], [29], we searched the Nkx3.1 promoter for possible EBS that could mediated ERG binding.
Herrera-Gayol and Jothy [42] showed that CD44 variants (especially CD44v6) could regulate the binding of breast cancer cells to extracellular HA, and these binding interactions could mediate tumor cell metastasis.
Our results open the possibility that direct protamine binding to RyR2 could mediate, at least in part, the observed abnormalities in SR Ca2+ homeostasis.
EHDs possess several domains that could potentially mediate various functions.
Lauren et al. reported that PrPC could mediate Aβ toxicity18.
So, I realized that I could mediate.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com