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This indicates multiple unspecific binding targets recognized by JFC12T10 in a broad variety of cell lines, including the HEK293-TKTL1 transfectants.
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Here we have identified potential target genes with well-described DNA binding sites recognized by the -KTS isoform and have not assessed the less well understood RNA binding sites recognized by the +KTS isoform [ 60].
Using the Popdc2 gene as an example, we also show that a significant proportion of target genes for NKX2-5 contain a binding motif recognized by NKX2-5, which overlaps with a binding site for MEIS1.
The binding sites and target sequence recognized by RelBE-like proteins are unknown in M. tuberculosis.
First, computational analysis has revealed that the ALK binding site recognized by β-catenin substantially overlaps with that of crizotinib22.
This induces opsin to expose intracellular binding regions recognized by G-proteins.
However, variability in the DNA binding sequences recognized by TF binding domains may complicate the results.
Transcription factor gene paralogs in particular, can diversify either by changes in their tissue-specific expression pattern or by changes in the DNA binding site motif recognized by their protein product, which in turn alters their gene targets.
This suggests that either individual histones not available for binding in chromatin preparations (i.e., H3, H4) or other components of chromatin may be the targets being recognized by the autoantibodies in these individuals.
The yellow shadow marks the target sequence recognized by crRNA.
Specific nuclear DNA κB binding sites are efficiently recognized by RelB/p52 DNA heterodimers, allowing for transcription of certain κB-regulated target genes [49], [51].
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