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Interestingly, large portions of ARF6 binding targets overlapped with either targets of BZR1 (51%) or PIF4 (71%) or both (42%).
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2. The reviewer asked how many of the Hairy binding sites on the 167 genes scored as direct targets overlap with active enhancers.
Again the highest scoring binding pocket (R=50) overlapped with the heme binding site.
Furthermore, nearly 50% of RXRα bindings overlapped with the bindings of PXR, LXR, FXR, and PPARα.
Second, their in-vivo binding profiles will overlap with p63 binding profile.
Moreover, several significant TF binding peaks overlap with these enhancers.
We found that TFs that are significantly more co-expressed with the other TFs show a fourfold decrease in the overlap between their knockout and binding targets compared with TFs that are significantly less co-expressed with the other TFs.
CtrA's binding sites are overlapping with a DnaA box and the IHF binding site.
The microvesicle binding surface partially overlaps with the chemokine receptor interface.
The predicted binding sites for 028 completely overlapped with the catalytic site of IspA and overlapped with the substrate binding site and Mg2+ ion binding site of IspB.
Numbers of significant AZF1 and TRB1 target genes overlapping with Col-0 biased genes.
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