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That is, only 3% of the binding targets of a TF are indeed regulated by this TF.
Surprisingly, they found that only 3% of the binding targets of a TF are affected by the knockout of this TF.
These methods are all based on one assumption: most, if not all, binding targets of a TF are regulated by this TF.
ChIP-chip analysis can only identify the binding targets of a TF but it cannot distinguish the true regulatory from the binding but non-regulatory targets of a TF [ 17].
Biologists are puzzled by the extremely low percentage (3%) of the binding targets of a yeast transcription factor (TF) affected when the TF is knocked out, a phenomenon observed by comparing the TF binding dataset and TF knockout effect dataset.
This study gives a plausible biological explanation of a counterintuitive phenomenon: most binding targets of a yeast transcription factor are not affected when the transcription factor is knocked out.
Similar(46)
The fifth carbon budget will help us meet the UK's legally binding target of an at least 80% reduction in greenhouse gas emissions by 2050".
Campaigners claim E.ON's plans to build the UK's first new coal-fired power station for 20 years at Kingsnorth in Kent — as well as a reported 17 coal-fired power stations across Europe — will render impossible the UK's binding target of an 80% cut in greenhouse gas emissions by 2050.
Both scenarios seek to achieve the UK's legally binding target of an 80% reduction in GHG emissions from 1990 levels by 2050.
The known binding targets of dsRBZFPs form an evolutionarily disparate but structurally similar group of both endogenous and exogenous double-stranded RNAs.
"Rich countries are undermining the entire climate regime, particularly the binding targets of the Kyoto protocol.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com