Because every primary tissue contains different sets of transcription factors, chromatin remodelers, and, indeed, chromatin structures, the presence of a commonly bound set of genes that makes up the large majority of E2F4 binding targets in multiple human (or mouse) tissues suggests that this key member of the DREAM complex binds independently of the above factors.
Until now, there is no indication of connectivity of Zic3 and c-Myc, with one exception: in 2006, Zeller et al. found that the Zic3 binding motifs are significantly enriched in c-Myc-repressed genes after a genome-wide characterization of direct c-Myc binding targets in a model of human B lymphoid tumor using ChiP coupled with pair-end ditag sequencing analysis (ChiP-PET).
Searching for possible immunocontraceptive targets in human spermatozoa by using yeast two-hybrid system, Naz and Dhandapani [19] recently identified the ubiquitin-binding, proteasome-associating protein UBAP2L as the most likely binding partner of human ZPC protein.
Here, we identified 1469 Myc direct binding target genes in HeLa cells and human foreskin fibroblasts using human core promoter microarrays.
The HF target in human cells is human EPRS.
However, despite the conservation of the overall regulatory regime and putative target genes between mouse and human adipocytes the retention of mouse binding sites in human is limited, i.e. most sites are species-specific.
3– 7 We characterized a comprehensive set of NRSF target genes relevant to human neuronal functions by analyzing ChIP-Seq datasets of NRSF binding sites in human ESC and the corresponding ESC-derived neurons, retrieved from the public database.
Drugs can bind different protein targets in the human organism.
The jump will result in Britain missing binding targets to reduce child poverty by 2020.
