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The fifth carbon budget will help us meet the UK's legally binding target of an at least 80% reduction in greenhouse gas emissions by 2050".
Campaigners claim E.ON's plans to build the UK's first new coal-fired power station for 20 years at Kingsnorth in Kent — as well as a reported 17 coal-fired power stations across Europe — will render impossible the UK's binding target of an 80% cut in greenhouse gas emissions by 2050.
Both scenarios seek to achieve the UK's legally binding target of an 80% reduction in GHG emissions from 1990 levels by 2050.
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That is, only 3% of the binding targets of a TF are indeed regulated by this TF.
This assumption is supported by three computational studies which estimate about 60% of the binding targets of a TF are indeed the regulatory targets of this TF [ 6- 8].
Surprisingly, they found that only 3% of the binding targets of a TF are affected by the knockout of this TF.
These methods are all based on one assumption: most, if not all, binding targets of a TF are regulated by this TF.
ChIP-chip analysis can only identify the binding targets of a TF but it cannot distinguish the true regulatory from the binding but non-regulatory targets of a TF [ 17].
ChIP-chip analysis can only identify the binding targets of a TF but it cannot distinguish the true regulatory from the binding but non-regulatory targets of a TF.
Biologists are puzzled by the extremely low percentage (3%) of the binding targets of a yeast transcription factor (TF) affected when the TF is knocked out, a phenomenon observed by comparing the TF binding dataset and TF knockout effect dataset.
This study gives a plausible biological explanation of a counterintuitive phenomenon: most binding targets of a yeast transcription factor are not affected when the transcription factor is knocked out.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com