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In fact, these regions directly involve in biochemical functioning such as binding surfaces on the surface of proteins [14].
How these putative eIF2α-P binding surfaces on the eIF2Bα, -β, and -δ subunits come together to simultaneously interact with eIF2α has remained an open question.
Of note, our NOE data do not indicate binding of the MLL peptide to additional binding surfaces on the KIX domain.
This hypothesis was further supported by the HDX-MS analysis that suggested two distinct binding surfaces on the catalytic core of KDM4C located remote from the active site.
Necap 1 also exerts a regulatory input on AP-2 by competitively engaging several binding surfaces on the heterotetramer (Ritter et al., 2013).
This does not disprove the existence of other ZapC binding surfaces on the body of FtsZ that could lead to the reported nanomolar affinities [17].
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The identification of a procaspase-specific binding surface on the FADD DED suggests a preferential interaction with one, but not both, of the DEDs of procaspase-8 in a perpendicular arrangement.
Our experiments also indicate that a second binding surface on the Sho1p SH3 domain is required for its proper in vivo function.
In this study, NMR titration of Ub with AT3-UIM12 has given similar information of the binding surface on the Ub structure [33] centered by Leu8, Ile44 and Val70 (Fig. 5A).
Its binding surface on the protein is carpeted by an electropositive surface potential.
The bacterial binding surface on the CEACAM1 N-domain is the protein face composed of the beta strands C′′, C′, C, F and G (CFG for brevity).
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