Sentence examples for binding surface of the from inspiring English sources
Kobayashi, K. et al. Identification and characterization of the RNA binding surface of the pentatricopeptide repeat protein.
We hypothesized that a peptide designed to resemble the binding surface of the H-helix may serve as an effective disruptor of EGFR dimerization and activation.
Additionally, the extended structure endows a more hydrophilic binding surface of the R-configured peptide to facilitate its capture by its targeted protein.
A ligand multimerization problem that would yield suboptimal affinity resins, caused by a cysteine residue present at the binding surface of the Affibody ligands, could be circumvented by the generation of second-generation Affibody ligands (having cysteine to serine substitutions).
Development of small molecule inhibitors for TLR9 remains largely empirical due to lack of structural understanding of potential TLR9 antagonism by small molecules and due to the unusual topology of the ligand binding surface of the receptor.
NMR titration experiments mapped the binding surface of the hSRI domain to helices 1 and 2, and Biacore binding studies showed that the domain binds preferably to [Ser-2 + Ser-5]-phosphorylated CTD peptides containing two or more heptad repeats.
Such hydrophobic pockets have previously been reported for the OppA proteins [65] and help to orientate peptides within the binding surface of these proteins.
Although the actin binding surfaces of the bridge element are not directly blocked in this model, the trans interaction could lead to autoinhibition by at least two mechanisms.
In both models, engagement of the DAD by the N-terminus is incompatible with actin filament formation on the FH2, and in one model the actin binding surfaces of the FH2 domain are directly blocked by the N-terminus.
As such, there is very little overlap between the DH domain binding surfaces of the SH3 domain from Asef and SH3(E) from intersectin-1L, suggesting that these GEFs utilize distinct mechanisms of autoinhibition.
