Your English writing platform
Discover LudwigExact(1)
The "classical binding surface" is conserved (Table 1), and two substitutions are present that confer an increased affinity when introduced into human insulin.
Similar(59)
Overall, the two LPMO families share a conserved β-sandwich fold [ 11], and many residues on the substrate-binding surface are conserved.
Our analysis showed that the PSII-binding surface is highly conserved in all angiosperms.
Intriguingly, three of these key interacting residues of the PHD finger, including its two gatekeepers (D380 and T359) which separate the cleft from the HD1-binding surface, are highly conserved among all Pygo orthologs, from placozoa to humans, and the CF-interacting residue of B9L (T240 whose side-chain points into the cleft gate) is invariant among B9L and BCL9 orthologs.
This indicates that even though the binding location of DB00631 fluctuates with different peptides, the overall binding affinity is conserved.
Furthermore, an Rbpjκ binding site is conserved on the promoters of Nrf2 among animal species.
All positions are not highly conserved; however the hydrophobic nature of the binding site is conserved.
The Norrin Fz4CRD binding interface is conserved between the complex structures.
The binding site, M3, is conserved in 8 of them.
The C8γ-binding cysteine is conserved in the perforin-like domain.
In the case of pdc2Δ344 the DNA-binding and transactivation site are both intact, whereas in pdc2Δ519 only the DNA-binding site is conserved.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com