Sentence examples for binding surface and the from inspiring English sources

The FHA domain is linked to the kinase/phosphatase catalytic domain by a flexible tether, and it exhibits a mode of target selection based on electrostatic complementarity between the binding surface and the phosphothreonine peptide.

Our structural analysis involved comparison of the overall fold, the surface properties, the conformations of three loops contributing to the binding surface and the sequence identity of residues contributing to these loops.

The contribution of electrostatic interactions to the binding of RPA32C targets is evident from the charge complementarity of the acidic RPA32C binding surface and the presence of multiple basic residues in the target binding motifs.

This conclusion is based on the preponderance of mutations that map to the previously identified TFIIF binding surface and the similar phenotypes of mutants shown to have altered interactions with TFIIF.

This phosphorylation event induces a complete rotation of the linker region that unmasks the RING E2 binding surface and activates the ligase [ 20, 21].

The two new structures show changes at both the actin-binding surface and the active site that have not been observed previously.

Recent studies have suggested that DAX-1 is not exclusively a nuclear orphan receptor but can be also detected mainly in the cytoplasm, functioning as a potent corepressor for estrogen receptors in mammalian cells, presumably by the direct occupation of the coactivator-binding surface and the subsequent recruitment of additional corepressor [ 37].

Competitive displacement of substrate by GroES could account for its simultaneous ejection from the binding surface and encapsulation in the folding chamber but does not explain why there is no escape of substrate into solution at this step.

On the other hand, the structures of the Vasa protein from D. melanogaster, human Dbp5 and DDX19, showed a closed conformation, with both subdomains creating an RNA binding surface and contributing to the ATP binding site [5] [7].

Based on the data presented in this manuscript, we now suggest that the interaction between NOXO1 and NOXA1 relies solely on this additional binding surface and does not include the proline-rich region.

Collectively, our data define a putative binding surface and an overall orientation of the szDOv/sDM complex and have implications for the mechanism of DO inhibition of DM.