Sentence examples for binding substrate in an from inspiring English sources

However, using pure dsDNA as a binding substrate in an anti-dsDNA ELISA remains a laboratory artefact.

Unlike E. coli UPPS which follows an ordered substrate binding mechanism with FPP binding prior to IPP binding, our data for S. pneumoniae UPPS are consistent with a random-sequential substrate binding mechanism, with each substrate binding in a manner independent of the other (described by the dotted rectangle in Figure 9).

SPOUT structures utilize conserved residues to bind the AdoMet substrate in a binding cleft formed by the knot.

As substrate binding is believed to be coupled to protein conformational changes relevant to the transport cycle, describing the binding mode of the substrate in a detailed manner is one of the first steps in a mechanistic characterization of GlpT.

The AR protein binds the C-terminal lobe of APH and thereby stabilizes three α helices, which are necessary for substrate binding, in a significantly displaced conformation.

R269 was also suspected to contribute to substrate binding in a manner similar to that of R45, because of their symmetric arrangement in the crystal structure.

We speculate that phosphorylation on surface loops of Pellinos could inhibit substrate binding in a manner that mirrors the autoinhibition of Pellino3a by the Pellino3a specific insertion.

(53) The muCOX-2 1AG muCOX-2 1AGgain revealstructurete binding in againductive conforeveals in monomer B and an unproductive conformation in monomer A; however, the differencesubstratetwo conformations are more subindingan those seen in the muCOX-2:aA structure.

Thus, while Compound 1 closely mimics the binding of substrate in the FtDHPS module, it only partially mimics substrate binding in the FtHPPK module.

Presence of a substrate in a binding site results in elimination of complexed water molecule.

The insertions in the kinase domain of CylM preclude binding of the CylA peptide substrate in a similar pose.