Sentence examples for binding subsites close to from inspiring English sources

Amino acid sequence analysis revealed a clear trend in cyclodextrin product specificity based on the nature of various amino acids at the donor substrate binding subsites, close to the active site.

The relative lack of specificity of the enzyme at several subsites close to the scissile bond can be rationalized by the structural studies, which demonstrate that these pockets allow the ligand side chains to adopt more than one conformation.

The length of the tryptophan-rich substrate binding groove suggests the presence of substrate binding subsites −4 to +3.

The design and synthetic efforts were directed towards novel modifications to explore the protease binding region close to the S4 subsite.

The cyclization reaction starts with binding of a linear saccharide chain across the nine sugar binding subsites labelled −7 to +2 (Fig.  1; Strokopytov et al. 1996), with glycosidic bond cleavage occurring between the −1 and +1 subsites, to yield a stable covalent glycosyl enzyme intermediate (Uitdehaag et al. 1999b).

This docking region comprises the entire transmembrane region since the binding subsites reported up to date for substrates and inhibitors reside in the cell membrane, involving residues located in the transmembrane helices [ 23].

These binding energies are close to the reported values of the binding state of Zn2+[19].

Extended Data Fig. 1 METTL3 binding close to the stop codon enhances translation.

The issues that are less economically impactful, or are non-binding, are close to being resolved.

Replacing Gly23 and 65 of the S1 binding subsite to phenylalanine resulted in partial or complete loss of affinity for the substrate.

Together with the conserved catalytic triad at the active site, variability was observed for secondary binding subsites that may contribute to the proper substrate alignment and could explain the distinct substrate preference patterns.