Sentence examples for binding study of compound from inspiring English sources

In silico binding study of compound 5d with plasmodial cysteine protease falcipain-2 indicated the inhibition of falcipain-2 as the probable reason for the antimalarial potency of compound 5d.

In silico binding study of compound 5d with plasmodial cysteine protease falcipain-2 shows that inhibition of falcipain-2 could be the probable reason for the potency shown by compound 5d.

It is well-known that preclinical pharmacokinetic study including plasma pharmacokinetics, tissue distribution, and protein binding study of a compound can be extrapolated to human and helps us to understand and predict its behavior in clinic [ 31].

In addition, in vitro stability, solubility and plasma binding studies of the compounds 17 and 26 showed them to be metabolically stable.

The DNA binding studies of the synthesized compounds with CT-DNA were carried out by UV vis and fluorescence spectroscopy.

Our results are consistent with the earlier binding studies of BmrR to three cationic compounds (Table 1) and crystal structures obtained for the resulting complexes [27].

Also, docking study of compound 11l in the BZD-binding site of GABAA receptor confirms possible binding of compound 11l with BZD receptors.

A molecular docking study of compound 4a was performed to gain an insight into its binding mode with xanthine oxidase.

To further characterize the binding mode of AZD2995, competition binding studies with unlabelled compound were conducted using either Aβ 1-40) or Aβ 1-42) fibrils at different concentrations of [H]PIB (0.5 35 nM) as described previously [ 15].

Docking study of compounds 7a, 7e and 9 into the COX-2 binding site revealed a similar binding mode to SC-558, a selective COX-2 inhibitor.

In agreement with competition-binding studies of MCTs expressed in yeast for related compounds [ 30], we have shown that AR-C155858 inhibits both MCT1 and MCT2, but not MCT4 when expressed in oocytes.