Sentence examples for binding studies with different from inspiring English sources
A structure-based mapping of the active site by mutations and binding studies with different substrates was used to determine the molecular basis for product inhibition and guided the development of MHETase variants with enhanced activity towards MHET or even an altered substrate specificity towards BHET.
Because CAIA experiments gave such a rapid response and also an apparent knee inflammation in both the mouse strains, we were prompted to perform in vivo binding studies with different monoclonal antibodies.
A macrocyclic fluorescent receptor was designed and synthesised and the binding study with three different types of dicarboxylic acids was performed with the receptor being found to have appreciable association constants.
To further characterize the binding mode of AZD2995, competition binding studies with unlabelled compound were conducted using either Aβ 1-40) or Aβ 1-42) fibrils at different concentrations of [H]PIB (0.5 35 nM) as described previously [ 15].
Direct binding studies with K1374R demonstrated no significant alteration in binding to the lower affinity site; however, binding to the high affinity site is reduced by 83%.
Kinetic binding studies with blank CHO-K1 cells revealed no radiotracer uptake & low unspecific binding (n = 3).
A selection of characterized mutations were previously engineered into recombinant H5 HA proteins and their effects on SA binding studied with red blood cells from different species [17], [18] or using synthetic glycans which act as receptor mimetics [19], [20], [21].
Despite striking functional similarities, radioligand binding studies revealed different mGluR5 binding profiles for DFB and CDPPB compared with those of CPPHA (19, 21, 27).
Fcγ receptor (FcγR) binding studies using different Fcγ receptors revealed that different rituximab glycoforms show a clearly different binding affinity for FcγRs.
Fluorescent ligands have several advantages over traditional radio-ligand binding techniques [ 161] and studies with different neuropeptides comparing radio-ligand with fluorescent ligand binding revealed a higher resolution with fluo-peptides [ 96].
Studies on its binding with different metal ions reveal a noticeable naked eye color change, bathochromic shift in absorption spectrum and remarkable enhancement in fluorescence emission in the presence of Cu2+ only.
