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Moreover direct binding studies confirmed that recombinant αv β3 binds to vitronectin (a positive control) and β43 63 in a solid-phase assay.
In vitro binding studies confirmed that TAF7L forms complexes with both TBP and PPARγ.
As previously reported, binding studies confirmed that HBL melanoma cells had a relatively high receptor number.
Genome-wide mRNA-seq expression profiling and ChIP-seq binding studies confirmed that TAF7L is required for activating adipocyte-specific genes via a dual mechanism wherein it interacts with PPARγ at enhancers and TBP/Pol II at core promoters.
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Radioligand binding studies confirm that muscarinic receptors in the bladder of humans and animals largely belong to the M2 subtype, with a smaller contribution of M3 and even smaller one of other subtypes [ 67 69].
In conclusion, volunteer studies and pre-clinical receptor-binding studies confirm that ZD4054 is a potent antagonist of ETA, with no evidence of ETB blockade at doses upto 240 mg in volunteers and at 10 μ M in vitro.
Taxonomic studies confirm that F. nucleatum ssp.
Previous studies confirmed that SHC binding to RET is crucial for the transforming activity of RET mutant proteins [ 71].
Moreover, biochemical studies confirmed that the binding of Smad3 to Imp8 is regulated by RanGTP, suggesting that Smads are bona fide cargos of Msk/Imp7/Imp8 [ 33].
Acriflavine did, and further studies confirmed that it was binding directly to HIF-1.
Recent benchmarking studies confirmed that transcription factor binding sites (TFBS) prediction based on statistical motif discovery approaches is unreliable and thus remains a major bottleneck in the study of transcriptional regulatory regions [1], [2].
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