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The observed binding structure could be beneficial for the design of potent aminopeptidase inhibitors.
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Furthermore, RNA binding motifs may be very flexible and other RNA residues in addition to the 'UGUA' core motif or RNA structure could be important for the in vivo APUM5 binding system.
It is very possible that microcin J25 binding to bacterial RNAP, for which there is no current RNAP microcin J25 structure, could be modeled on the basis of RNAP II−α-amanitin structures.
Changing the dual structure could be difficult.
In addition, such dependency of the binding specificity on the preformed structures could be utilized for the design of high-affinity and sequence-specific heparin-binding polypeptides.
Since the membrane-binding properties of α-Syn are thought to be relevant for its pathologic activity [1], [9], [10], we speculated that also for synphilin-1 the binding to different types of lipid structures could be linked to its inclusion formation.
The interaction with LC3 may imply that a binding of AMBRA1 with other ATG proteins on LC3-positive structures could be required for correct autophagosome maturation.
No ocular structures could be identified.
Because all of these structures have more than one ligand that binds to protein, we had a large number of ligand-protein binding structures that could be used for in silico drug screening using chooseLD.
The structure of human Mediator changes upon TF binding, which could be utilized as a conformational "marker" to process transcriptional signals.
In addition, overlay of the Stat3 and Stat1 structuresurevealedaled that the loops that contained these binding sites could be superimposed (Figure 3H).
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