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To develop the new test, the team modified existing technology to select relevant portions of the genome by binding stretches of complementary DNA to the regions of interest, drawing them out of a soup of DNA.
Upon addition of Pif1, a new population with EFRET = 0.37 appeared because protein binding stretches ssDNA (Yang et al., 2013).
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Here, an N × 8 matrix was computed containing explicitly the degree of conservation at each position of the aligned 8-residue binding stretch for each of the N zinc finger domains.
RNAbindR [36,37] predicts two RNA-binding stretches within aa 76 109 and 387 476 in axotrophin.
To confirm this finding, we analysed the enrichment of OCT1-binding stretches derived from previous ChIP-seq study 26 in the synbindin promoter.
Tight-fitting rubber foot bindings stretch in case of a fall, releasing the skier's feet without injury.
This nuclear localization may be determined by the first RNA-binding stretch aa 76 109.
All DME paralogs contain an N-terminal lysine-rich region that in ROS1 is necessary for binding long stretches of DNA in a methylation-independent manner.
First, ISWI, INO80/SWR1 and CHD require extra-nucleosomal DNA to remodel nucleosomes, whereby they are primarily involved in nucleosome assembly and generating equally spaced arrays by binding to stretches of exposed DNA and shifting nucleosomes into the gap (Whitehouse et al., 2003; McKnight et al., 2011; Udugama et al., 2011).
Furthermore, they must be locked in through binding commitments, stretching decades into the future and reinforced by market-based emissions-trading mechanisms.
Our approach was validated by the co-identification of both the gene's TATA box and a previously characterized dimeric GATA binding site stretching from −179 to −165 [37].
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CEO of Professional Science Editing for Scientists @ prosciediting.com