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Modulation of an interaction by modification of multiple residues even allows for rheostatic control of binding strength, where the affinity for an interaction partner is gradually altered by multiple modifications that additively enhance or diminish the interaction.
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This is shown in Fig. 8, where the binding strength of the NTF is varied.
It assumes that the stronger binding sites are occupied first and that the binding strength decreases as the rate at which the sites are occupied increases.
They determined that the binding strength increased with the increasing chain length of the perfluorinated compound.
It is assumed that the stronger binding sites are occupied first and that the binding strength decreases with the increasing degree of site occupation.
The binding strength and the number of binding sites were determined at different ionic strengths.
Consequently, pristine clay yields the highest binding strength to the nylon.
Sites were sorted for binding strength within the three subsets.
The binding strength is determined by the binding free energy, Δ G bind.
Within the conserved TF binding regions shared among all five mouse species, we observed more than 7,000 loci where the TF binding strength is constrained, and these loci, perhaps surprisingly, do not appear to be concentrated near functional target genes.
In which way is the optimum binding strength related to exchange dynamics at the channel ends?
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