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BSA and the number of contacts at the interface are of course somewhat related, but the number of interface contacts shows much better correlations with binding strength than the BSA.
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Vinculin −/− cells expressing the head domain displayed a higher binding strength than those expressing the tail domain.
Fascinatingly, the complexes were found to exhibit greater binding strength than that of the free ligands.
These two mechanisms let the H-bond networks and hydrophobic interactions ruptured simultaneously in inhibitor ABT538 bound complex with higher binding strength than those in the AHA001 and XK263 bound complexes.
In general, Hya derivates showed higher binding strength than CS derivatives.
PFNA, PFUnDA, and PFDoDA showed less binding strength than PFOS and PFOA (Weiss et al. 2009).
The present study confirmed these results and further demonstrated that although they have lower ribosomal binding strength than ORFs, transcribed pseudogenes have higher ribosomal binding strength than non-transcribed pseudogenes.
However, examination of the crystal structures available for these targets reveals more the difficulties of structure based prediction of comparative binding strengths than mechanisms for doing so.
They determined that the binding strength increased with the increasing chain length of the perfluorinated compound.
Therefore, the actual binding strength of the Gr/Si superlattice may be somewhat stronger than our current LDA result.
Tetraphosphonate cavitand host (4iPO 1) was shown to impact more markedly n-Bu4NCl reactivity than triphosphonate counterpart (3iPO 3) due to its greater binding strength toward the ammonium cation as evidenced by titration experiments.
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