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Oligomerization offers functional advantages including multivalency, increased binding strength and the combined function of different domains.
The binding strength and the number of binding sites were determined at different ionic strengths.
Moreover, the binding strength and the conformation of ss-siRNA depend on the nature of the interactions between the ss-siRNA and the surfaces.
On the 0.5 and 1.0 ML Pd/Mo(1 1 0) surfaces, the binding strength and the degree of dissociation of hydrogen and ethylene were significantly reduced as compared to Mo(1 1 0) and thick Pd films.
Although the physicochemical properties that govern the efficacy and activity of PBAE-based nanoparticles are currently under investigation and likely include the chemical structure and molecular weight of the polymer, the polymer DNA binding strength, and the cellular uptake pathway of the nanoparticles, the exact mechanisms have not yet been fully elucidated.
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Two free parameters controlled the integrin and cadherin binding strength, and these are prescribed by the user adjusting "slider-bars".
We suggested that the stability of H-bond network between inhibitors and the PR dominates the binding strength and therefore the dissociation rate of the inhibitors.
The ROC curves again show that dCaP-T2-pair performs consistently better than the other two methods at all levels of binding strengths, and the performance of DIME is better than ANOVA in the strong and weak binding data.
We analyze the effects of GAG length and sulfation patterns in binding strength and specificity, and the influence of GAG binding on IL-8 dimer formation.
Degradation of RNA increases the fraction of absent probes paralleled by the decrease of the specific binding strength and counterbalanced by the increase of non-specific background hybridization.
In order to enhance synthesis efficiency and also increase the flexibility of chemical manipulation, some of the aptamers were truncated, and the binding strength and apparent Kds of the truncated sequences were also assessed.
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