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all-trans-Retinol is oriented in the binding pocket with its hydroxyl group facing the solvent and the retinyl moiety snuggly bound by a number of nonpolar residues in a highly complementary fashion, explaining the high binding specificity toward the all-trans isomer.
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Based on computational results, the binding capacity showed that the highest binding specificity toward Tr could achieved when using pyrrole (PY) as the monomer in dimethyl sulfoxide (DMSO) solution to form a polymer matrix.
This suggested that structural details on the ligand are driving the small differences in binding specificity toward either TIR1 or AFB5 and that these details may be uncovered by the second factor (Factor 2 = Specificity).
Past studies have shown that the isoform8 has phosphoinositide binding specificity toward PI 4,5 P2 in vitro.
This residue is a major determinant of substrate binding specificity toward a productive binding mode.
This is in agreement with their expected binding specificity toward pPGM epitope glycans, Gal (RCA and PNA) and Fuc (UEA) (Table 1 ).
We wanted to determine if selective pressures act on these proteins and to check if positive selection may play a role in binding specificity toward ligands or olfactory receptors.
This result further demonstrates the binding specificity of the RBFOX1/2 binding motif and suggests that the SRSF1 motif would not efficiently interact with RBFOX1/2 proteins.
Xu, H. et al. Collagen binding specificity of the discoidin domain receptors: binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1.
Boer, D. R. et al. Structural basis for DNA binding specificity by the auxin-dependent ARF transcription factors.
Recent structural and biochemical studies have focused on understanding the glycan receptor binding specificity of the 1957-58 pandemic H2N2 HA.
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