Our results suggest that morphological divergence is not driven by subtle drift in specificity of TFs, but primarily caused by cis-regulatory changes (Carroll, 2000; Levine and Tjian, 2003), with some contribution from relatively large shifts in binding specificities of specific TFs.
Thus, the observed levels may not reflect the levels in vivo due to absence of O. cincta specific transcription factors or altered binding specificity of Drosophila transcription factors to O. cincta specific transcription factor binding sites.
In order to determine the binding specificity of A10-2 to GP73, the specific anti-GP73 antibody was used to evaluate whether it could block the interaction between GP73 and A10-2.
Human tissue samples were used to evaluate the clinical relevance of hTMEM27 by assessing tissue-specific production and binding specificity of 8/9-mAb to TMEM27 in adult human normal tissue microarrays.
Isotope-edited spectroscopic analysis and binding specificity of these complexes provides information about specific enzyme transition state contacts.
The binding specificity of collagelin was determined using the GPVI specific ligand, collagen related peptide (CRP), and various different macromolecules from the extracellular matrix.
To determine the binding specificity of selected soluble scFv fragments, E. coli HB2151 was infected with specific phage selected on different antigens.
This competitive binding of LTKE, specific to mutant cells and to the peptide amino acid sequence, clearly indicates the binding specificity of the LTKE peptide towards hGBE1 p.Y329S.
